1. Personal Information
1>Name：JIN Si, M.D., Ph.D.
2>Title:Professor, Chief Physician
3>Department:Tongji Medical College，Huazhong University of Science and Technology，Wuhan, Hubei, P. R. China 430030
5>Email:jinsi@hust.edu.cn
2. Biography
EDUCATION
M.D. Tongji Medical College, Huazhong University of Science and Technology, China 1998
M.S.Tongji Medical College, Huazhong University of Science and Technology, China 2002
Ph.D. Tongji Medical College, Huazhong University of Science and Technology, China 2005
PROFESSIONAL EXPERIENCE
Professor Tongji Medical College, Huazhong University of Science and Technology 2010-present
Associate Professor Tongji Medical College, Huazhong University of Science and Technology 2005-2010
Lecture Tongji Medical College, Huazhong University of Science and Technology 2003-2005
Teaching Assistant Tongji Medical College, Huazhong University of Science and Technology 1998-2003
3. Boards, Advisory Committees, Professional Organizations
1. Executive member of geriatric medicine society of China.
2. Vice director of Hubei diabetology society.
4. Selected Publications
1: Shu M, Cheng W, Jia X, Bai X, Zhao Y, Lu Y, Zhu L, Zhu Y, Wang L, Shu Y, Song
Y,Jin S*. AGEs promote atherosclerosis by increasing LDL transcytosis across endothelial cells via RAGE/NF-κB/Caveolin-1 pathway.Mol Med.2023 Aug
21;29(1):113. doi: 10.1186/s10020-023-00715-5. PMID: 37605109;
2: Shu Y, Xiong Y, Song Y,Jin S*,Bai X*. Positive association between circulatingCaveolin-1 and microalbuminuria in overt diabetes mellitus in pregnancy.J Endocrinol Invest.2023 Jun 26. doi: 10.1007/s40618-023-02137-w. Epub ahead of print.
3: Cheng W, Shu M, Kuang L, Bai X, Jia X, Zhao Y, Lu Y, Zhu L, Wang L, Zhu Y, Shu Y, Song Y,Jin S*. Scavenger receptor a mediates glycated LDL transcytosis across endothelial cells to promote atherosclerosis.Int J Biol Macromol.2023 Feb 25;235:123836.
4: Jia X, Bai X, Yang X, Wang L, Lu Y, Zhu L, Zhao Y, Cheng W, Shu M, Mei Q,Jin S*. VCAM-1-binding peptide targeted cationic liposomes containing NLRP3 siRNA to modulate LDL transcytosis as a novel therapy for experimental atherosclerosis.Metabolism:Clinical and Experimental.2022 Oct;135:155274.
5：Zhao Y, Jia X, Yang X, Bai X, Lu Y, Zhu L, Cheng W, Shu M, Zhu Y, Wang L, Shu Y, Song Y，Jin S*. Deacetylation of Caveolin-1 by Sirt6 induces autophagy and retards high glucose-stimulated LDL transcytosis and atherosclerosis formation.Metabolism:Clinical and Experimental.2022 Jun;131:155162.Epub2022 Feb 12, 155162.
6: Zhu L, Yang X, Li J, Jia X, Bai X, Zhao Y, Cheng W, Shu M, Zhu Y,Jin S*. Leptin gene-targeted editing in ob/ob mouse adipose tissue based on the CRISPR/Cas9 system. J Genet Genomics. 2021 Feb 20;48(2):134-146. doi:10.1016/j.jgg.2021.01.008. Epub 2021 Mar 30. PMID: 33931338.
7: Yang Q, Tian C, Tseng B, Zhang B, Huang S,Jin S, Mao J. Gait Change in Dual Task as a Behavioral Marker to Detect Mild Cognitive Impairment in Elderly Persons: A Systematic Review and Meta-analysis. Arch Phys Med Rehabil. 2020 Oct;101(10):1813-1821. doi: 10.1016/j.apmr.2020.05.020.
8: Li J, Jiang Y, Xu T, Zhang Y, Xue J, Gao X, Yang X, Wang X, Jia X, Cheng W,Jin S*. Wilson Disease With Novel Compound Heterozygote Mutations in the ATP7B Gene Presenting With Severe Diabetes. Diabetes Care. 2020 Jun;43(6):1363-1365.
9: Bai X, Yang X, Jia X, Rong Y, Chen L, Zeng T, Deng X, Li W, Wu G, Wang L, Li Y, Zhang J, Xiong Z, Xiong L, Wang Y, Zhu L, Zhao Y,Jin S*. CAV1-CAVIN1-LC3B-mediated autophagy regulates high glucose-stimulated LDL transcytosis. Autophagy. 2020 Jun;16(6):1111-1129. Epub 2019 Aug 26.
10:Zheng T, Yang X, Wu D, Xing S, Bian F, Li W, Chi J, Bai X, Wu G, Chen X, Zhang Y,Jin S*. Salidroside ameliorates insulin resistance through activation of a mitochondria-associated AMPK/PI3K/Akt/GSK3β pathway.Br J Pharmacol.2015 Jul;172(13):3284-301.
11: Zhang Y, Yang X, Bian F, Wu P, Xing S, Xu G, Li W, Chi J, Ouyang C, Zhen T, Wu D, Zhang Y, Li Y, Jin S*. TNF-α promotes early atherosclerosis by increasing transcytosis of LDL across endothelial cells: crosstalk between NF-κB and PPAR-γ. J Mol Cell Cardiol. 2014 Mar 2;72C:85-94.
12: Bian F, Yang X, Zhou F, Wu PH, Xing S, Xu G, Li W, Chi J, Ouyang C, Zhang Y, Xiong B, Li Y, Zheng T, Wu D, Chen X, Jin S*. CRP promotes atherosclerosis by increasing LDL transcytosis across endothelial cells. Br J Pharmacol. (2014)171 2671–2684.
13: Jin S*, Zhou F, Katirai F, Li PL. Lipid raft redox signaling: molecular mechanisms in health and disease.Antioxid Redox Signal.15(4):1043-83. 2011.
14: Jin S, Yi F, Zhang F, Poklis JL, Li PL*. Lysosomal targeting and trafficking of acid sphingomyelinase to lipid raft platforms in coronary endothelial cells.Arterioscler Thromb Vasc Biol.28(11):2056-62. 2008.
15: Jin S,Zhang Y, Yi F, Li PL*. Critical role of lipid raft redox signaling platforms in endostatin-induced coronary endothelial dysfunction.Arterioscler Thromb Vasc Biol.28(3):485-90. 2008.
5.Projects, Fundings, Programs
National Natural Science Foundation of China(82370840,82070862)
Major Research Program of Ministry of Science ang Technology of China(2020YFC2008900)
